CNS

Alzheimer’s Disease

Primary culture of cortical neurons or primary culture of hippocampal neurons
• 1-42 Beta amyloid peptide injuries (injuries induced with oligomers of peptide, for information see Callizot et al., 2013)
• Glutamate and NMDA injuries
• TNF alpha injuries

Parkinson’s Disease

Primary culture of mesencephalic neurons (for information see Visanji et al., 2008)
• 6-hydroxydopamine injuries
• MPP+ injuries
• Rotenone injuries
• Injuries induced with oligomers (cf AD/PD poster Callizot et al. 2015 ; IAPRD Callizot et al., 2018)

Amyotrophic Lateral Sclerosis

Nerves / muscle co-culture (for information see Combes et al., 2015)
or primary culture of motorneurons (for information see Guettier-Sigrist et al., 2001)
• Glutamate injuries
• 1-42 Beta amyloid peptide injuries (for information see Combes et al., 2014)

Multiple Sclerosis

Full brain
• Myelinating co-culture of oligodendrocytes and central neurons
• Pharmacological and inflammatory demyelination

Huntington’s Disease

Primary culture of mesencephalic neurons
• Glutamate injuries
• Growth factor deprivation