PNS

Peripheral neuropathies
CHARCOT-MARIE-TOOTH MODELS, ANTI-MITOTIC…

Primary culture of sensory neurons
• Anti-mitotic agent injuries (taxol, vincristine, cisplatin)

Myelinating co-culture of Schwann cells / sensory neurons (wild type or PMP22 transgenic)
• Anti-mitotic agent injuries (taxol, vincristine, cisplatin)
• Pharmacological demyelination with Forskolin