PNS

 
 
Representative picture of a primary culture of sensory neurons immunolabeled with anti-MAP2 antibody

INDUCED PERIPHERAL NEUROPATHIES

In vitro models

  • Anti-mitotic agents (taxol, vincristine, cisplatin) on primary culture of sensory neurons, with or without differentiation of Schwann cells

  • Forskolin-induced demyelination in primary co-culture of sensory neurons and Schwann cells

CHARCOT-MARIE-TOOTH DISEASE

In vitro models

  • Primary co-culture of of sensory neurons and Schwann cells from PMP22 Tg animals (a model of CMT 1A)

Representative picture of a primary co-culture of sensory neurons and Schwann cells doubly immunolabeled with anti-MAG and anti-MBP antibodies