INDUCED PERIPHERAL NEUROPATHIES

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​In vitro models

• Anti-mitotic agents (taxol, vincristine, cisplatin) on primary culture of sensory neurons, with or without differentiation of Schwann cells

• Forskolin-induced demyelination in primary co-culture of sensory neurons and Schwann cells

CHARCOT-MARIE-TOOTH DISEASE

​In vitro models

• Primary co-culture of of sensory neurons and Schwann cells from PMP22 Tg animals (a model of CMT 1A)