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PRECLINICAL MODELS  |  CNS  |  ALS

Amyotrophic Lateral Sclerosis

IN VITRO models​

Nerves/muscle co-culture. Human muscle fibers innervated by rat spinal cord (SC) explants:

  • Glutamate injury

  • Amyloid-β1-42 peptide injuries

Primary culture of motorneurons wild type and transgenic animals (SOD 1)

  • Glutamate injury

  • Amyloid-β1-42 peptide injuries

IN VIVO models​

Sciatic nerve injury as an in vivo model to study motor axon regeneration and muscle reinnervation.

 

Regeneration of motor axons is studied by electromyography, function recovery and histology analysis of sciatic nerve and neuromuscular functions.