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PRECLINICAL MODELS | CNS | ALS
Amyotrophic Lateral Sclerosis
IN VITRO models
Nerves/muscle co-culture. Human muscle fibers innervated by rat spinal cord (SC) explants:
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Glutamate injury
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Amyloid-β1-42 peptide injuries
Primary culture of motorneurons wild type and transgenic animals (SOD 1)
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Glutamate injury
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Amyloid-β1-42 peptide injuries
IN VIVO models
Sciatic nerve injury as an in vivo model to study motor axon regeneration and muscle reinnervation.
Regeneration of motor axons is studied by electromyography, function recovery and histology analysis of sciatic nerve and neuromuscular functions.
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