Alzheimer disease hippocampe area AbO injection site GFAP in red nuclei in blue.jpg

PRECLINICAL MODELS  |  CNS  |  AD

Alzheimer's disease

IN VITRO models

 

Primary culture of cortical or hippocampal neurons co-cultured with glial cells (astrocytes and microglia): 

  • Amyloid-β1-42 peptide injuries (induced with oligomers of peptide, for information see Callizot et al., 2013)

  • Acute or chronic injuries (microglia activation)

  • Glutamate and NMDA injuries

  • TNF-α injuries / microglia activation

IN VIVO models

 

Intra-hippocampal injection of amyloid β1-42 oligomers in aged mice.

Combines the toxicity of amyloid beta oligomers and advanced ageing. Our model mimics the main pathologies of AD: neurodegeneration, activation of pro-inflammatory response, long-term and short-term memory deficit.

 

Validated with Donepezil, drug indicated for AD.